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产品信息
ABS 033-04-02
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
4
抗原
Synthetic GLP-1 (7-17).
偶联物
形式
Liquid
浓度
1.02 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1074636
产品详细信息
ABS 033-04-02 detects the amidated N-terminus of GLP-1(7-37) and GLP-1(7-36) in human samples.
ABS 033-04-02 has been successfully used in ELISA procedures. ABS 033-04-02 binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36) amide and shows < 0.2% cross-reactivity with GLP-1(1-37), GLP-1(9-36) amide, glucagon, human GIP and exendin-4. ABS 033-04-02 cross-reacts approximately 1% with human GLP-2. Not recommended for sandwich ELISA applications.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
靶标信息
GCG is also known as GLP1, or Glucagon. Glucagon is a 29-amino acid pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis.It is mapped to 2q36-2q37. GLP1, also known as 7-37 for the codons of the preproglucagon molecule which encode it, renders pancreatic beta-cells 'glucose-competent' and may be useful in the treatment of noninsulin-dependent diabetes mellitus. Also, GLP1 is a potent insulin secretagogue.It plays a major role in the enteroinsular axis, accounting, for example, for the finding that plasma insulin levels accompanying oral intake of glucose are greater than those observed when glucose is given intravenously.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: glicentin-related polypeptide; GLP1/2; Glucagon like peptide 1; glucagon-like peptide 1; glucagon-like peptide 2; MGC138331; OXY; preproglucagon; Pro-glucagon
基因别名: GCG; GLP1; GLP2; GRPP
UniProt ID: (Human) P01275
Entrez Gene ID: (Human) 2641
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
feeding behavior
cell proliferation
protein kinase A signaling
positive regulation of peptidyl-threonine phosphorylation
positive regulation of cAMP biosynthetic process
positive regulation of protein binding
negative regulation of appetite
positive regulation of peptidyl-serine phosphorylation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
response to starvation
negative regulation of apoptotic process
positive regulation of protein kinase activity
regulation of insulin secretion
positive regulation of histone H3-K4 methylation
positive regulation of ERK1 and ERK2 cascade
cellular response to glucagon stimulus
positive regulation of calcium ion import
negative regulation of execution phase of apoptosis
negative regulation of intrinsic apoptotic signaling pathway
